Spatio-selective activation of nuclear translocation of YAP with light directs invasion of cancer cell spheroids
Summary: The mechanical properties of the extracellular matrix strongly influence tumor progression and invasion. Yes-associated protein (YAP) has been shown to be a key regulator of this process translating mechanical cues from the extracellular matrix into intracellular signals. Despite its appare...
Main Authors: | Bernhard Illes, Adrian Fuchs, Florian Gegenfurtner, Evelyn Ploetz, Stefan Zahler, Angelika M. Vollmar, Hanna Engelke |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2021-03-01
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Series: | iScience |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422100153X |
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