Ticagrelor Conditioning Effects Are Not Additive to Cardioprotection Induced by Direct NLRP3 Inflammasome Inhibition: Role of RISK, NLRP3, and Redox Cascades

Ticagrelor Conditioning Effects Are Not Additive to Cardioprotection Induced by Direct NLRP3 Inflammasome Inhibition: Role of RISK, NLRP3, and Redox Cascades

Inhibition of either P2Y12 receptor or the nucleotide-binding oligomerization domain- (NOD-) like receptor pyrin domain containing 3 (NLRP3) inflammasome provides cardioprotective effects. Here, we investigate whether direct NLRP3 inflammasome inhibition exerts additive effects on myocardial protect...

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Bibliographic Details
Main Authors: Claudia Penna, Manuela Aragno, Alessia Sofia Cento, Saveria Femminò, Isabella Russo, Federica Dal Bello, Fausto Chiazza, Debora Collotta, Gustavo Ferreira Alves, Massimo Bertinaria, Elisa Zicola, Valentina Mercurio, Claudio Medana, Massimo Collino, Pasquale Pagliaro
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2020/9219825

Internet

http://dx.doi.org/10.1155/2020/9219825

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