Investigation of the Membrane Fluidity Regulation of Fatty Acid Intracellular Distribution by Fluorescence Lifetime Imaging of Novel Polarity Sensitive Fluorescent Derivatives

Investigation of the Membrane Fluidity Regulation of Fatty Acid Intracellular Distribution by Fluorescence Lifetime Imaging of Novel Polarity Sensitive Fluorescent Derivatives

Free fatty acids are essential structural components of the cell, and their intracellular distribution and effects on membrane organelles have crucial roles in regulating the metabolism, development, and cell cycle of most cell types. Here we engineered novel fluorescent, polarity-sensitive fatty ac...

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Bibliographic Details
Main Authors: Giada Bianchetti, Salome Azoulay-Ginsburg, Nimrod Yosef Keshet-Levy, Aviv Malka, Sofia Zilber, Edward E. Korshin, Shlomo Sasson, Marco De Spirito, Arie Gruzman, Giuseppe Maulucci
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
fatty acids analogs
laurdan derivatives
FLIM
membrane fluidity
two-photons microscopy
phasor analysis
Online Access:https://www.mdpi.com/1422-0067/22/6/3106

Internet

https://www.mdpi.com/1422-0067/22/6/3106

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