Long non-coding RNA MEG3 mediates the miR-149-3p/FOXP3 axis by reducing p53 ubiquitination to exert a suppressive effect on regulatory T cell differentiation and immune escape in esophageal cancer

Long non-coding RNA MEG3 mediates the miR-149-3p/FOXP3 axis by reducing p53 ubiquitination to exert a suppressive effect on regulatory T cell differentiation and immune escape in esophageal cancer

Abstract Background Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) has been implicated in the progression of esophageal cancer (EC). However, the specific mechanism of the involvement of MEG3 in EC development in relation to the regulation of immune escape remains uncertain. Thus, t...

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Bibliographic Details
Main Authors: Qi-Rong Xu, Jian Tang, Hong-Ying Liao, Ben-Tong Yu, Xiang-Yuan He, Yu-Zhen Zheng, Sheng Liu
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Translational Medicine
Subjects:
Esophageal cancer
LncRNA MEG3
MDM2
p53
miR-149-3p
FOXP3
Online Access:https://doi.org/10.1186/s12967-021-02907-1

Internet

https://doi.org/10.1186/s12967-021-02907-1

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