Iterative structure-based peptide-like inhibitor design against the botulinum neurotoxin serotype A.

Iterative structure-based peptide-like inhibitor design against the botulinum neurotoxin serotype A.

The botulinum neurotoxin serotype A light chain (BoNT/A LC) protease is the catalytic component responsible for the neuroparalysis that is characteristic of the disease state botulism. Three related peptide-like molecules (PLMs) were designed using previous information from co-crystal structures, sy...

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Bibliographic Details
Main Authors: Jorge E Zuniga, Jared T Hammill, Omri Drory, Jonathan E Nuss, James C Burnett, Rick Gussio, Peter Wipf, Sina Bavari, Axel T Brunger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2894858?pdf=render

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http://europepmc.org/articles/PMC2894858?pdf=render

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