Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects.

Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects.

Elucidating the causes of congenital heart defects is made difficult by the complex morphogenesis of the mammalian heart, which takes place early in development, involves contributions from multiple germ layers, and is controlled by many genes. Here, we use a conditional/invertible genetic strategy...

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Bibliographic Details
Main Authors: Rosaysela Santos, Shimako Kawauchi, Russell E Jacobs, Martha E Lopez-Burks, Hojae Choi, Jamie Wikenheiser, Benedikt Hallgrimsson, Heather A Jamniczky, Scott E Fraser, Arthur D Lander, Anne L Calof
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-09-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC5016002?pdf=render

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http://europepmc.org/articles/PMC5016002?pdf=render

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