Valproic acid potentiates curcumin-mediated neuroprotection in Lipopolysaccharide induced rats

Valproic acid potentiates curcumin-mediated neuroprotection in Lipopolysaccharide induced rats

The etiology of neuroinflammation is complex and comprises multifactorial, involving both genetic and environmental factors during which diverse genetic and epigenetic modulations are implicated. Curcumin (Cur), and valproic acid (VPA), histone deacetylase 1 inhibitor, have neuroprotective effects....

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Bibliographic Details
Main Authors: Amira eZaky, Mariam eMahmoud, Doaa eAwad, Bassma M El Sabaa, Kamal M. Kandeel, Ahmad R. Bassiouny
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Neuroinflammation
lipopolysaccharide (LPS)
curcumin (Cur)
valproic acid (VPA)
let-7 miRNA
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00337/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00337/full

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