Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology

Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology

Abstract Background Methionine, a central molecule in one-carbon metabolism, is an essential amino acid required for normal growth and development. Despite its importance to biological systems, methionine is toxic when administered at supra-physiological levels. The aim of this study was to investig...

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Bibliographic Details
Main Authors: Isabelle R. Miousse, Rupak Pathak, Sarita Garg, Charles M. Skinner, Stepan Melnyk, Oleksandra Pavliv, Howard Hendrickson, Reid D. Landes, Annie Lumen, Alan J. Tackett, Nicolaas E.P. Deutz, Martin Hauer-Jensen, Igor Koturbash
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Genes & Nutrition
Subjects:
Burkholderiales
Essential amino acid
Gut microbiome
LINE-1
Methionine toxicity
Tight junction-related proteins
Online Access:http://link.springer.com/article/10.1186/s12263-017-0576-0

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http://link.springer.com/article/10.1186/s12263-017-0576-0

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