NGF signaling in PC12 cells: the cooperation of p75NTR with TrkA is needed for the activation of both mTORC2 and the PI3K signalling cascade

NGF signaling in PC12 cells: the cooperation of p75NTR with TrkA is needed for the activation of both mTORC2 and the PI3K signalling cascade

Summary PC12-27, a PC12 clone characterized by high levels of the transcription repressor REST and by very low mTORC2 activity, had been shown to be unresponsive to NGF, possibly because of its lack of the specific TrkA receptor. The neurotrophin receptor repressed by high REST in PC12-27 cells, how...

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Bibliographic Details
Main Authors: Sara Negrini, Rosalba D'Alessandro, Jacopo Meldolesi
Format: Article
Language:English
Published: The Company of Biologists 2013-07-01
Series:Biology Open
Subjects:
REST
PC12-27
ERK and PI3K cascades
mTORC2
mTORC1-dependent feed-back inhibition
Online Access:http://bio.biologists.org/content/2/8/855

Internet

http://bio.biologists.org/content/2/8/855

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