Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction

Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction

Motor deficits are among the most frequent impairments in Down syndrome (DS), but their neuropathological and molecular bases remain elusive. Here we investigate the motor profile of transgenic mice overexpressing Dyrk1a, Tg(Dyrk1a)1Cff (hereafter TgDyrk1a), a candidate gene hypothesized to cause so...

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Bibliographic Details
Main Authors: M Martı́nez de Lagrán, X Altafaj, X Gallego, E Martı́, X Estivill, I Sahún, C Fillat, M Dierssen
Format: Article
Language:English
Published: Elsevier 2004-02-01
Series:Neurobiology of Disease
Subjects:
Down syndrome
Dyrk1a
Motor dysfunction
DYRK1A expression
Motor learning
Transgenic mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103002055

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http://www.sciencedirect.com/science/article/pii/S0969996103002055

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