Low-coverage whole-genome sequencing of extracellular vesicle-associated DNA in patients with metastatic cancer

Low-coverage whole-genome sequencing of extracellular vesicle-associated DNA in patients with metastatic cancer

Abstract Low-coverage whole-genome sequencing (LC-WGS) can provide insight into oncogenic molecular changes. Serum extracellular vesicles (EV) represent a novel liquid biopsy source of tumoral DNA. This study compared copy number alteration (CNA) profiles generated from LC-WGS of formalin-fixed para...

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Bibliographic Details
Main Authors: Bella Nguyen, Nicholas C. Wong, Tim Semple, Michael Clark, Stephen Q. Wong, Connull Leslie, Bob Mirzai, Michael Millward, Katie Meehan, Annette M. Lim
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83436-1

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https://doi.org/10.1038/s41598-021-83436-1

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