Pilot Study of Delayed ICOS/ICOS-L Blockade With αCD40 to Modulate Pathogenic Alloimmunity in a Primate Cardiac Allograft Model

Pilot Study of Delayed ICOS/ICOS-L Blockade With αCD40 to Modulate Pathogenic Alloimmunity in a Primate Cardiac Allograft Model

Background. Inducible costimulator (ICOS) is rapidly upregulated with T-cell stimulation and may represent an escape pathway for T-cell costimulation in the setting of CD40/CD154 costimulation blockade. Induction treatment exhibited no efficacy in a primate renal allograft model, but rodent transpla...

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Bibliographic Details
Main Authors: Natalie A. O’Neill, MD, Tianshu Zhang, MD, PhD, Gheorghe Braileanu, PhD, Xiangfei Cheng, MD, PhD, Alena Hershfeld, MS, Wenji Sun, MD, PhD, Keith A. Reimann, PhD, Sia Dahi, MD, Natalia Kubicki, MD, Wessam Hassanein, MD, Christopher Laird, MD, Arielle Cimeno, MD, Agnes M. Azimzadeh, PhD, Richard N. Pierson, MD
Format: Article
Language:English
Published: Wolters Kluwer 2018-02-01
Series:Transplantation Direct
Online Access:http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000000761

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http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000000761

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