Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease

Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease

Abstract Background Huntington disease (HD) is a fatal neurodegenerative disorder caused by a CAG expansion in the huntingtin (HTT) gene, leading to selective and progressive neuronal death predominantly in the striatum. Mutant HTT expression causes dysfunctional cortico-striatal (CS) transmission,...

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Bibliographic Details
Main Authors: Mandi E. Schmidt, Caodu Buren, James P. Mackay, Daphne Cheung, Louisa Dal Cengio, Lynn A. Raymond, Michael R. Hayden
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Biology
Subjects:
Huntington disease
huntingtin
synapse
spine
dendrite
corticostriatal co-culture
Online Access:http://link.springer.com/article/10.1186/s12915-018-0526-3

Internet

http://link.springer.com/article/10.1186/s12915-018-0526-3

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