Co-Stimulation of BCR and Toll-Like Receptor 7 Increases Somatic Hypermutation, Memory B Cell Formation, and Secondary Antibody Response to Protein Antigen

Co-Stimulation of BCR and Toll-Like Receptor 7 Increases Somatic Hypermutation, Memory B Cell Formation, and Secondary Antibody Response to Protein Antigen

The goal of immunization is to produce both a flood of antibodies to neutralize antigen and memory cells to accelerate the secondary response. To enhance the generation of memory B cells, we examined the effect of co-engaging BCR and toll-like receptor (TLR) 7 receptors by immunizing mice with a hap...

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Bibliographic Details
Main Authors: Diana P. Castiblanco, Robert W. Maul, Lisa M. Russell Knode, Patricia J. Gearhart
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
memory B cell
BCR
toll-like receptor 7
germinal center
somatic hypermutation
vaccine
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01833/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01833/full

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