Aneuploidy in targeted endoscopic biopsies outperforms other tissue biomarkers in the prediction of histologic progression of Barrett's oesophagus: A multi-centre prospective cohort study

Aneuploidy in targeted endoscopic biopsies outperforms other tissue biomarkers in the prediction of histologic progression of Barrett's oesophagus: A multi-centre prospective cohort study

Background: The cancer risk in Barrett's oesophagus (BO) is difficult to estimate. Histologic dysplasia has strong predictive power, but can be missed by random biopsies. Other clinical parameters have limited utility for risk stratification. We aimed to assess whether a molecular biomarker pan...

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Bibliographic Details
Main Authors: Andreas V. Hadjinicolaou, Sanne N. van Munster, Achilleas Achilleos, Jose Santiago Garcia, Sarah Killcoyne, Krish Ragunath, Jacques J.G.H.M. Bergman, Rebecca C. Fitzgerald, Massimiliano di Pietro
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:EBioMedicine
Subjects:
Barrett's oesophagus
Histologic progression
Dysplasia
Oesophageal adenocarcinoma
Biomarkers
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420301407

Internet

http://www.sciencedirect.com/science/article/pii/S2352396420301407

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