Characterization of B- and T-Cell Compartment and B-Cell Related Factors Belonging to the TNF/TNFR Superfamily in Patients With Clinically Active Systemic Lupus Erythematosus: Baseline BAFF Serum Levels Are the Strongest Predictor of Response to Belimumab after Twelve Months of Therapy

Characterization of B- and T-Cell Compartment and B-Cell Related Factors Belonging to the TNF/TNFR Superfamily in Patients With Clinically Active Systemic Lupus Erythematosus: Baseline BAFF Serum Levels Are the Strongest Predictor of Response to Belimumab after Twelve Months of Therapy

Background: Patients with systemic lupus erythematosus (SLE) show increased serum levels of tumor necrosis factor (TNF)/TNF receptor (R) superfamily member, e.g. BAFF (B lymphocyte stimulator). Belimumab, a monoclonal antibody against soluble BAFF, is used for treatment of SLE. Although B cells are...

Full description

Bibliographic Details
Main Authors: Silvia Piantoni, Francesca Regola, Stefania Masneri, Michele Merletti, Torsten Lowin, Paolo Airò, Angela Tincani, Franco Franceschini, Laura Andreoli, Georg Pongratz
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
systemic lupus erythematosus
belimumab
biomarkers
TNF/TNFR superfamily-related factors
adaptive immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.666971/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.666971/full

Similar Items