Phylogenetic conservation of the 3’ cryptic recombination signal sequence (cRSS) in the VH genes of jawed vertebrates

Phylogenetic conservation of the 3’ cryptic recombination signal sequence (cRSS) in the VH genes of jawed vertebrates

The VH replacement process is a RAG-mediated secondary recombination in which the variable region of a rearranged VHDJH is replaced by a different germline VH gene. In almost all human and mouse VH genes, two sequence features appear to be crucial for VH replacement. First, an embedded heptamer, whi...

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Bibliographic Details
Main Authors: Yi eSun, Zhancai eLiu, Zhaoyong eLi, Zhengxing eLian, Yaofeng eZhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-12-01
Series:Frontiers in Immunology
Subjects:
immunoglobulin
vertebrate
VH replacement
3’cRSS
VH replacement footprint
charged amino acid
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00392/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00392/full

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