Tumor Evolution and Intratumor Heterogeneity of an Oropharyngeal Squamous Cell Carcinoma Revealed by Whole-Genome Sequencing

Tumor Evolution and Intratumor Heterogeneity of an Oropharyngeal Squamous Cell Carcinoma Revealed by Whole-Genome Sequencing

Head and neck squamous cell carcinoma (HNSCC) is characterized by significant genomic instability that could lead to sclonal diversity. Intratumor clonal heterogeneity has been proposed as a major attribute underlying tumor evolution, progression, and resistance to chemotherapy and radiation. Under...

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Bibliographic Details
Main Authors: Xinyi Cindy Zhang, Chang Xu, Ryan M. Mitchell, Bo Zhang, Derek Zhao, Yao Li, Xin Huang, Wenhong Fan, Hongwei Wang, Luisa Angelica Lerma, Melissa P. Upton, Ashley Hay, Eduardo Méndez, Lue Ping Zhao
Format: Article
Language:English
Published: Elsevier 2013-12-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558613800061

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http://www.sciencedirect.com/science/article/pii/S1476558613800061

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