Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is Implicated in Tumorigenesis

Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is Implicated in Tumorigenesis

Summary: The histone methyl transferase enhancer of zeste homolog 2 (EZH2) is a master transcriptional regulator involved in histone H3 lysine 27 trimethylation. We aimed to elucidate the precise post-translational regulations of EZH2 and their role in cancer pathogenesis. Here, we show that SET and...

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Main Authors: Yi Zeng, Rongfang Qiu, Yang Yang, Tianyang Gao, Yu Zheng, Wei Huang, Jie Gao, Kai Zhang, Ruiqiong Liu, Shuang Wang, Yongqiang Hou, Wenqian Yu, Shuai Leng, Dandan Feng, Wei Liu, Xi Zhang, Yan Wang
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719312975

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http://www.sciencedirect.com/science/article/pii/S2211124719312975

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