Icaritin Inhibits Collagen Degradation-Related Factors and Facilitates Collagen Accumulation in Atherosclerotic Lesions: A Potential Action for Plaque Stabilization

Icaritin Inhibits Collagen Degradation-Related Factors and Facilitates Collagen Accumulation in Atherosclerotic Lesions: A Potential Action for Plaque Stabilization

Most acute coronary syndromes result from rupture of vulnerable atherosclerotic plaques. The collagen content of plaques may critically affect plaque stability. This study tested whether Icaritin (ICT), an intestinal metabolite of Epimedium-derived flavonoids, could alter the collagen synthesis/degr...

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Bibliographic Details
Main Authors: Zong-Kang Zhang, Jie Li, De-Xin Yan, Wing-Nang Leung, Bao-Ting Zhang
Format: Article
Language:English
Published: MDPI AG 2016-01-01
Series:International Journal of Molecular Sciences
Subjects:
Icaritin
atherosclerosis
plaque stabilization
matrix metalloproteinase
collagen
Online Access:http://www.mdpi.com/1422-0067/17/2/169

Internet

http://www.mdpi.com/1422-0067/17/2/169

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