Autoimmunity in CD73/Ecto-5'-nucleotidase deficient mice induces renal injury.

Autoimmunity in CD73/Ecto-5'-nucleotidase deficient mice induces renal injury.

Extracellular adenosine formed by 5'-ectonucleotidase (CD73) is involved in tubulo-glomerular feedback in the kidney but is also known to be an important immune modulator. Since CD73(-/-)mutant mice exhibit a vascular proinflammatory phenotype, we asked whether long term lack of CD73 causes inf...

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Bibliographic Details
Main Authors: Cornelia Blume, Agnieszka Felix, Nelli Shushakova, Faikah Gueler, Christine Susanne Falk, Hermann Haller, Juergen Schrader
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3362584?pdf=render

Internet

http://europepmc.org/articles/PMC3362584?pdf=render

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