Nasal Rifampicin Improves Cognition in a Mouse Model of Dementia with Lewy Bodies by Reducing α-Synuclein Oligomers

Nasal Rifampicin Improves Cognition in a Mouse Model of Dementia with Lewy Bodies by Reducing α-Synuclein Oligomers

α-Synuclein oligomers are thought to play an important role in the pathogenesis of dementia with Lewy bodies (DLB). There is no effective cure for DLB at present. Previously, we demonstrated that in APP- and tau-transgenic mice, oral or intranasal rifampicin reduced brain Aβ and tau oligomers and im...

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Bibliographic Details
Main Authors: Tomohiro Umeda, Yukari Hatanaka, Ayumi Sakai, Takami Tomiyama
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
rifampicin
intranasal administration
α-synuclein
oligomer
dementia with Lewy bodies
prevention
Online Access:https://www.mdpi.com/1422-0067/22/16/8453

Internet

https://www.mdpi.com/1422-0067/22/16/8453

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