Nasal Rifampicin Improves Cognition in a Mouse Model of Dementia with Lewy Bodies by Reducing α-Synuclein Oligomers
α-Synuclein oligomers are thought to play an important role in the pathogenesis of dementia with Lewy bodies (DLB). There is no effective cure for DLB at present. Previously, we demonstrated that in APP- and tau-transgenic mice, oral or intranasal rifampicin reduced brain Aβ and tau oligomers and im...
Main Authors: | Tomohiro Umeda, Yukari Hatanaka, Ayumi Sakai, Takami Tomiyama |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-08-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/22/16/8453 |
Similar Items
-
Alpha-synuclein oligomers - neurotoxic molecules in Parkinson’s disease and other Lewy body disorders
by: Martin Ingelsson
Published: (2016-09-01) -
Studies of α-synuclein Oligomers-with Relevance to Lewy Body Disorders
by: Fagerqvist, Therese
Published: (2013) -
Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy
by: Omar El-Agnaf, et al.
Published: (2017-08-01) -
The Role of α-Synuclein Oligomers in Parkinson’s Disease
by: Xiao-yu Du, et al.
Published: (2020-11-01) -
Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies
by: Attems, J., et al.
Published: (2022)