Myosin light chain kinase () coding polymorphisms modulate human lung endothelial cell barrier responses via altered tyrosine phosphorylation, spatial localization, and lamellipodial protrusions

Myosin light chain kinase () coding polymorphisms modulate human lung endothelial cell barrier responses via altered tyrosine phosphorylation, spatial localization, and lamellipodial protrusions

Sphingosine 1-phosphate (S1P) is a potent bioactive endogenous lipid that signals a rearrangement of the actin cytoskeleton via the regulation of non-muscle myosin light chain kinase isoform (nmMLCK). S1P induces critical nmMLCK Y 464 and Y 471 phosphorylation resulting in translocation of nmMLCK to...

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Bibliographic Details
Main Authors: Ting Wang, Mary E. Brown, Gabriel T. Kelly, Sara M. Camp, Joseph B. Mascarenhas, Xiaoguang Sun, Steven M. Dudek, Joe G.N. Garcia
Format: Article
Language:English
Published: SAGE Publishing 2018-03-01
Series:Pulmonary Circulation
Online Access:https://doi.org/10.1177/2045894018764171

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https://doi.org/10.1177/2045894018764171

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