Dynorphin activation of kappa opioid receptor promotes microglial polarization toward M2 phenotype via TLR4/NF-κB pathway

Dynorphin activation of kappa opioid receptor promotes microglial polarization toward M2 phenotype via TLR4/NF-κB pathway

Abstract Background Microglia-mediated neuroinflammation is associated with epilepsy. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic strategy for mitigating epileptogenesis. We previously found that dynorp...

Full description

Bibliographic Details
Main Authors: Lin Liu, Yingtong Xu, Hongmei Dai, Shan Tan, Xiao Mao, Zhiheng Chen
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Cell & Bioscience
Subjects:
Dynorphin
Prodynorphin
Microglia
M1
M2 polarization
TLR4
Online Access:http://link.springer.com/article/10.1186/s13578-020-00387-2

Internet

http://link.springer.com/article/10.1186/s13578-020-00387-2

Similar Items