A combinatorial code for splicing silencing: UAGG and GGGG motifs.
Alternative pre-mRNA splicing is widely used to regulate gene expression by tuning the levels of tissue-specific mRNA isoforms. Few regulatory mechanisms are understood at the level of combinatorial control despite numerous sequences, distinct from splice sites, that have been shown to play roles in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2005-05-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC1079783?pdf=render |