TAT-protein blockade during ischemia/reperfusion reveals critical role for p85 PI3K-PTEN interaction in cardiomyocyte injury.

TAT-protein blockade during ischemia/reperfusion reveals critical role for p85 PI3K-PTEN interaction in cardiomyocyte injury.

Recent work shows that cooling protection after mouse cardiac arrest and cardiomyocyte ischemia is mediated by Akt activation. The PI3K p85 subunit can either augment or inhibit Akt activation depending on its binding to p110 or PTEN respectively. To further clarify the role of PI3K p85 in cardiopro...

Full description

Bibliographic Details
Main Authors: Xiangdong Zhu, Zuo-Hui Shao, Changqing Li, Jing Li, Qiang Zhong, Jonathan Learoyd, Angelo Meliton, Lucille Meliton, Alan R Leff, Terry L Vanden Hoek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3994094?pdf=render

Internet

http://europepmc.org/articles/PMC3994094?pdf=render

Similar Items