Immunometabolic Network Interactions of the Kynurenine Pathway in Cutaneous Malignant Melanoma

Immunometabolic Network Interactions of the Kynurenine Pathway in Cutaneous Malignant Melanoma

Dysregulation of the kynurenine pathway has been regarded as a mechanism of tumor immune escape by the enzymatic activity of indoleamine 2, 3 dioxygenase and kynurenine production. However, the immune-modulatory properties of other kynurenine metabolites such as kynurenic acid, 3-hydroxykynurenine,...

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Main Authors: Soudabeh Rad Pour, Hiromasa Morikawa, Narsis A. Kiani, David Gomez-Cabrero, Alistair Hayes, Xiaozhong Zheng, Maria Pernemalm, Janne Lehtiö, Damian J. Mole, Johan Hansson, Hanna Eriksson, Jesper Tegnér
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Oncology
Subjects:
kynurenine pathway
cutaneous malignant melanoma
immune metabolic network interactions
3-hydroxykynurenine
CD4+ T helper (Th) cells
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00051/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00051/full

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