Heat shock protein-90 inhibitors enhance antigen expression on melanomas and increase T cell recognition of tumor cells.

Heat shock protein-90 inhibitors enhance antigen expression on melanomas and increase T cell recognition of tumor cells.

In an effort to enhance antigen-specific T cell recognition of cancer cells, we have examined numerous modulators of antigen-expression. In this report we demonstrate that twelve different Hsp90 inhibitors (iHsp90) share the ability to increase the expression of differentiation antigens and MHC Clas...

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Bibliographic Details
Main Authors: Timothy J Haggerty, Ian S Dunn, Lenora B Rose, Estelle E Newton, Franco Pandolfi, James T Kurnick
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4264751?pdf=render

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http://europepmc.org/articles/PMC4264751?pdf=render

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