p62/SQSTM1-dependent autophagy of Lewy body-like α-synuclein inclusions.

p62/SQSTM1-dependent autophagy of Lewy body-like α-synuclein inclusions.

α-Synuclein is the main component of Lewy bodies, the intraneuronal inclusion bodies characteristic of Parkinson's disease. Although α-synuclein accumulation is caused by inhibition of proteasome and autophagy-lysosome, the degradation of α-synuclein inclusions is still unknown. Formation of Le...

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Bibliographic Details
Main Authors: Yoshihisa Watanabe, Harutsugu Tatebe, Katsutoshi Taguchi, Yasuhisa Endo, Takahiko Tokuda, Toshiki Mizuno, Masanori Nakagawa, Masaki Tanaka
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3534125?pdf=render

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http://europepmc.org/articles/PMC3534125?pdf=render

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