Antibacterial Activity of the Non-Cytotoxic Peptide (p-BthTX-I)2 and Its Serum Degradation Product against Multidrug-Resistant Bacteria

Antimicrobial peptides can be used systemically, however, their susceptibility to proteases is a major obstacle in peptide-based therapeutic development. In the present study, the serum stability of p-BthTX-I (KKYRYHLKPFCKK) and (p-BthTX-I)2, a p-BthTX-I disulfide-linked dimer, were analyzed by mass...

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Bibliographic Details
Main Authors: Norival A. Santos-Filho, Rafaela S. Fernandes, Bruna F. Sgardioli, Matheus A. S. Ramos, Julia P. Piccoli, Ilana L. B. C. Camargo, Tais M. Bauab, Eduardo M. Cilli
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/22/11/1898