CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance[S]

CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance[S]

Mutations of Comparative Gene Identification-58 (CGI-58) in humans cause triglyceride (TG) accumulation in multiple tissues. Mice genetically lacking CGI-58 die shortly after birth due to a skin barrier defect. To study the role of CGI-58 in integrated lipid and energy metabolism, we utilized antise...

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Bibliographic Details
Main Authors: J. Mark Brown, Jenna L. Betters, Caleb Lord, Yinyan Ma, Xianlin Han, Kui Yang, Heather M. Alger, John Melchior, Janet Sawyer, Ramesh Shah, Martha D. Wilson, Xiuli Liu, Mark J. Graham, Richard Lee, Rosanne Crooke, Gerald I. Shulman, Bingzhong Xue, Hang Shi, Liqing Yu
Format: Article
Language:English
Published: Elsevier 2010-11-01
Series:Journal of Lipid Research
Subjects:
fatty liver
insulin resistance
triglyceride hydrolysis
lipoprotein secretion
fatty acid oxidation
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520409642

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http://www.sciencedirect.com/science/article/pii/S0022227520409642

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