Synaptic tau: A pathological or physiological phenomenon?

Abstract In this review, we discuss the synaptic aspects of Tau pathology occurring during Alzheimer’s disease (AD) and how this may relate to memory impairment, a major hallmark of AD. Whilst the clinical diagnosis of AD patients is a loss of working memory and long-term declarative memory, the his...

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Bibliographic Details
Main Authors: Miranda Robbins, Emma Clayton, Gabriele S. Kaminski Schierle
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Acta Neuropathologica Communications
Subjects:
Tau
Online Access:https://doi.org/10.1186/s40478-021-01246-y