Kinome-Wide RNA Interference Screening Identifies Mitogen-Activated Protein Kinases and Phosphatidylinositol Metabolism as Key Factors for Rabies Virus Infection

Kinome-Wide RNA Interference Screening Identifies Mitogen-Activated Protein Kinases and Phosphatidylinositol Metabolism as Key Factors for Rabies Virus Infection

Rabies virus relies on cellular machinery for its replication while simultaneously evading the host immune response. Despite their importance, little is known about the key host factors required for rabies virus infection. Here, we focused on the human kinome, at the core of many cellular pathways,...

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Bibliographic Details
Main Authors: Benoit Besson, Seonhee Kim, Taehee Kim, Yoonae Ko, Sangchul Lee, Florence Larrous, Jihwan Song, David Shum, Regis Grailhe, Hervé Bourhy
Format: Article
Language:English
Published: American Society for Microbiology 2019-05-01
Series:mSphere
Subjects:
RNA interference
drug screening
inositol phosphate phosphatases
mitogen-activated protein kinases
rabies
Online Access:https://doi.org/10.1128/mSphere.00047-19

Internet

https://doi.org/10.1128/mSphere.00047-19

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