Bacteria-Induced Acute Inflammation Does Not Reduce the Long-Term Reconstitution Capacity of Bone Marrow Hematopoietic Stem Cells

Bacteria-Induced Acute Inflammation Does Not Reduce the Long-Term Reconstitution Capacity of Bone Marrow Hematopoietic Stem Cells

Pathogen-initiated chronic inflammation or autoimmune diseases accelerate proliferation and promote differentiation of hematopoietic stem cells (HSCs) but simultaneously reduce reconstitution capacity. Nevertheless, the effect of acute infection and inflammation on functional HSCs is still largely u...

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Bibliographic Details
Main Authors: Xiaoyu Zhang, Kutay Karatepe, Direkrit Chiewchengchol, Haiyan Zhu, Rongxia Guo, Peng Liu, Hongbo Yu, Qian Ren, Xiao Luo, Tao Cheng, Fengxia Ma, Yuanfu Xu, Mingzhe Han, Hongbo R. Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
hematopoietic stem cells
acute infection
inflammation
long-term reconstitution
self-renewal
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00626/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00626/full

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