Synthesis and Antiproliferative Activities of 5-Azacytidine Analogues in Human Leukemia Cells

Synthesis and Antiproliferative Activities of 5-Azacytidine Analogues in Human Leukemia Cells

Twenty-six 5-azacytidine analogues have been synthesized, including 4-amino- 6-alkyl-1-pyranosyl/ribofuranosyl-1,3,5-triazin-2(1H)-ones 1a-j, 6-amino-4-alkyl/aryl-1- pyranosyl/ribofuranosyl-1,3,5-triazin-2(1H)-ones 2a-f and 4-amino-6-alkyl-1,3,5-triazin-2- yl-1-thio-pyranosides/ribofuranosides 3a-j....

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Bibliographic Details
Main Authors: Lin-Xiang Zhao, Yong-Kui Jing, Yu Liu, Qian-Jiao Yang, Dan Liu, Gang Li, Gang Guo
Format: Article
Language:English
Published: MDPI AG 2008-07-01
Series:Molecules
Subjects:
5-Azacytidine analogues
antiproliferative activity
differentiation
leukemia
structure-activity relationship.
Online Access:http://www.mdpi.com/1420-3049/13/7/1487/

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http://www.mdpi.com/1420-3049/13/7/1487/

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