Mevastatin-Induced AP-1-Dependent HO-1 Expression Suppresses Vascular Cell Adhesion Molecule-1 Expression and Monocyte Adhesion on Human Pulmonary Alveolar Epithelial Cells Challenged with TNF-α

Mevastatin-Induced AP-1-Dependent HO-1 Expression Suppresses Vascular Cell Adhesion Molecule-1 Expression and Monocyte Adhesion on Human Pulmonary Alveolar Epithelial Cells Challenged with TNF-α

Mevastatin (MVS) has been previously shown to induce heme oxygenase (HO)-1 expression through Nox/ROS-dependent PDGFRα/PI3K/Akt/Nrf2/ARE axis in human pulmonary alveolar epithelial cells (HPAEpiCs). However, alternative signaling pathways might involve in MVS-induced HO-1 expression. We fou...

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Bibliographic Details
Main Authors: Chuen-Mao Yang, Chih-Chung Lin, Chien-Chung Yang, Rou-Ling Cho, Li-Der Hsiao
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Biomolecules
Subjects:
mevastatin
ho-1
nf-κb
vcam-1
c-jun/ap-1
human
Online Access:https://www.mdpi.com/2218-273X/10/3/381

Internet

https://www.mdpi.com/2218-273X/10/3/381

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