Monosodium Urate Crystals Activate the Inflammasome in Primary Progressive Multiple Sclerosis

Monosodium Urate Crystals Activate the Inflammasome in Primary Progressive Multiple Sclerosis

Inflammasome-driven inflammation is postulated to play a role in multiple sclerosis (MS), but there is no direct evidence that the nod-like receptor protein 3 (NLRP3) inflammasome is involved in MS pathogenesis. Uric acid was shown to be one of the “danger” signals involved in the activation of NLRP...

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Bibliographic Details
Main Authors: Federica Piancone, Marina Saresella, Ivana Marventano, Francesca La Rosa, Maria Antonia Santangelo, Domenico Caputo, Laura Mendozzi, Marco Rovaris, Mario Clerici
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis
inflammasome
uric acid
neuroinflammation
immunity
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00983/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00983/full

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