PTEN Deficiency Contributes to the Development and Progression of Head and Neck Cancer

PTEN Deficiency Contributes to the Development and Progression of Head and Neck Cancer

The sequencing of the head and neck cancer has provided a blueprint of the most frequent genetic alterations in this cancer type. They include inactivating mutations in Notch, p53, and p16ink4a tumor suppressor genes, in addition to nonoverlapping activating mutations of the PIK3CA and RAS oncogene...

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Bibliographic Details
Main Authors: Cristiane H Squarize, Rogerio M Castilho, Aline C Abrahao, Alfredo Molinolo, Mark W Lingen, J Silvio Gutkind
Format: Article
Language:English
Published: Elsevier 2013-05-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558613800322

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http://www.sciencedirect.com/science/article/pii/S1476558613800322

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