FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes

FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes

Summary: The contribution of adipose-derived FGF21 to energy homeostasis is unclear. Here we show that browning of inguinal white adipose tissue (iWAT) by β-adrenergic agonists requires autocrine FGF21 signaling. Adipose-specific deletion of the FGF21 co-receptor β-Klotho renders mice unresponsive t...

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Bibliographic Details
Main Authors: Mohammad Abu-Odeh, Yuan Zhang, Shannon M. Reilly, Nima Ebadat, Omer Keinan, Joseph M. Valentine, Maziar Hafezi-Bakhtiari, Hadeel Ashayer, Lana Mamoun, Xin Zhou, Jin Zhang, Ruth T. Yu, Yang Dai, Christopher Liddle, Michael Downes, Ronald M. Evans, Steven A. Kliewer, David J. Mangelsdorf, Alan R. Saltiel
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Cell Reports
Subjects:
Browning
Beiging
beige
adipose
adrenergic
FGF21
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721007075

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http://www.sciencedirect.com/science/article/pii/S2211124721007075

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