Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function

Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function

BRCA1 is a well-known DNA repair pathway component and a tissue-specific tumor suppressor. However, its role in hematopoiesis is uncertain. Here, we report that a cohort of patients heterozygous for BRCA1 mutations experienced more hematopoietic toxicity from chemotherapy than those with BRCA2 mutat...

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Bibliographic Details
Main Authors: Victoria E. Mgbemena, Robert A.J. Signer, Ranjula Wijayatunge, Travis Laxson, Sean J. Morrison, Theodora S. Ross
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
hematopoiesis
hematopoietic stem cells
pancytopenia
Fanconi anemia
BRCA1 mutations
gene targeting
Cre
humanization
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716317971

Internet

http://www.sciencedirect.com/science/article/pii/S2211124716317971

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