Mitochondrial DNA damage: Molecular marker of vulnerable nigral neurons in Parkinson's disease

Mitochondrial DNA damage: Molecular marker of vulnerable nigral neurons in Parkinson's disease

DNA damage can cause (and result from) oxidative stress and mitochondrial impairment, both of which are implicated in the pathogenesis of Parkinson's disease (PD). We therefore examined the role of mitochondrial DNA (mtDNA) damage in human postmortem brain tissue and in in vivo and in vitro mod...

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Bibliographic Details
Main Authors: Laurie H. Sanders, Jennifer McCoy, Xiaoping Hu, Pier G. Mastroberardino, Bryan C. Dickinson, Christopher J. Chang, Charleen T. Chu, Bennett Van Houten, J.T. Greenamyre
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Mitochondrial DNA damage
Abasic sites
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114001788

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http://www.sciencedirect.com/science/article/pii/S0969996114001788

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