Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress

Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress

The nucleolus is a specialized functional domain of the nucleus where ribosome biogenesis is initiated and also implicated in a p53-dependent anti-tumor surveillance. Here the authors use a quantitative imaging approach to detail the role of each ribosomal protein on the structural integrity of the...

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Main Authors: Emilien Nicolas, Pascaline Parisot, Celina Pinto-Monteiro, Roxane de Walque, Christophe De Vleeschouwer, Denis L. J. Lafontaine
Format: Article
Language:English
Published: Nature Publishing Group 2016-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11390
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spelling doaj-a3e1be32abf34328a408ce075cdfbd0f2021-05-11T10:50:16ZengNature Publishing GroupNature Communications2041-17232016-06-017111210.1038/ncomms11390Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stressEmilien Nicolas0Pascaline Parisot1Celina Pinto-Monteiro2Roxane de Walque3Christophe De Vleeschouwer4Denis L. J. Lafontaine5RNA Molecular Biology, F.R.S./FNRS, Université Libre de BruxellesICTEAM-ELEN, Université catholique de LouvainRNA Molecular Biology, F.R.S./FNRS, Université Libre de BruxellesRNA Molecular Biology, F.R.S./FNRS, Université Libre de BruxellesICTEAM-ELEN, Université catholique de LouvainRNA Molecular Biology, F.R.S./FNRS, Université Libre de BruxellesThe nucleolus is a specialized functional domain of the nucleus where ribosome biogenesis is initiated and also implicated in a p53-dependent anti-tumor surveillance. Here the authors use a quantitative imaging approach to detail the role of each ribosomal protein on the structural integrity of the nucleolus and p53 homeostasis.https://doi.org/10.1038/ncomms11390
collection DOAJ
language English
format Article
sources DOAJ
author Emilien Nicolas
Pascaline Parisot
Celina Pinto-Monteiro
Roxane de Walque
Christophe De Vleeschouwer
Denis L. J. Lafontaine
spellingShingle Emilien Nicolas
Pascaline Parisot
Celina Pinto-Monteiro
Roxane de Walque
Christophe De Vleeschouwer
Denis L. J. Lafontaine
Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress
Nature Communications
author_facet Emilien Nicolas
Pascaline Parisot
Celina Pinto-Monteiro
Roxane de Walque
Christophe De Vleeschouwer
Denis L. J. Lafontaine
author_sort Emilien Nicolas
title Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress
title_short Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress
title_full Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress
title_fullStr Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress
title_full_unstemmed Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress
title_sort involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-06-01
description The nucleolus is a specialized functional domain of the nucleus where ribosome biogenesis is initiated and also implicated in a p53-dependent anti-tumor surveillance. Here the authors use a quantitative imaging approach to detail the role of each ribosomal protein on the structural integrity of the nucleolus and p53 homeostasis.
url https://doi.org/10.1038/ncomms11390
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AT pascalineparisot involvementofhumanribosomalproteinsinnucleolarstructureandp53dependentnucleolarstress
AT celinapintomonteiro involvementofhumanribosomalproteinsinnucleolarstructureandp53dependentnucleolarstress
AT roxanedewalque involvementofhumanribosomalproteinsinnucleolarstructureandp53dependentnucleolarstress
AT christophedevleeschouwer involvementofhumanribosomalproteinsinnucleolarstructureandp53dependentnucleolarstress
AT denisljlafontaine involvementofhumanribosomalproteinsinnucleolarstructureandp53dependentnucleolarstress
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