A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors

A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors

Current therapies for glioblastoma multiforme (GBM), the highest grade malignant brain tumor, are mostly ineffective, and better preclinical model systems are needed to increase the successful translation of drug discovery efforts into the clinic. Previous work describes a genetically engineered mou...

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Bibliographic Details
Main Authors: Rajaa El Meskini, Anthony J. Iacovelli, Alan Kulaga, Michelle Gumprecht, Philip L. Martin, Maureen Baran, Deborah B. Householder, Terry Van Dyke, Zoë Weaver Ohler
Format: Article
Language:English
Published: The Company of Biologists 2015-01-01
Series:Disease Models & Mechanisms
Subjects:
Glioblastoma
Mouse model
PI3K and MEK inhibition
Apoptosis
Online Access:http://dmm.biologists.org/content/8/1/45

Internet

http://dmm.biologists.org/content/8/1/45

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