HEYL Regulates Neoangiogenesis Through Overexpression in Both Breast Tumor Epithelium and Endothelium

HEYL Regulates Neoangiogenesis Through Overexpression in Both Breast Tumor Epithelium and Endothelium

Blocking tumor angiogenesis is an appealing therapeutic strategy, but to date, success has been elusive. We previously identified HEYL, a downstream target of Notch signaling, as an overexpressed gene in both breast cancer cells and as a tumor endothelial marker, suggesting that HEYL overexpression...

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Bibliographic Details
Main Authors: Liangfeng Han, Preethi Korangath, Nguyen K. Nguyen, Adam Diehl, Soonweng Cho, Wei Wen Teo, Leslie Cope, Manfred Gessler, Lewis Romer, Saraswati Sukumar
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Oncology
Subjects:
breast
cancer
endothelium
HEYL
notch
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.581459/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.581459/full

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