A Genome-Wide CRISPR/Cas9 Screen Reveals the Requirement of Host Sphingomyelin Synthase 1 for Infection with Pseudorabies Virus Mutant gD<sup>–</sup>Pass

A Genome-Wide CRISPR/Cas9 Screen Reveals the Requirement of Host Sphingomyelin Synthase 1 for Infection with Pseudorabies Virus Mutant gD<sup>–</sup>Pass

Herpesviruses are large DNA viruses, which encode up to 300 different proteins including enzymes enabling efficient replication. Nevertheless, they depend on a multitude of host cell proteins for successful propagation. To uncover cellular host factors important for replication of pseudorabies virus...

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Bibliographic Details
Main Authors: Julia E. Hölper, Finn Grey, John Kenneth Baillie, Tim Regan, Nicholas J. Parkinson, Dirk Höper, Thiprampai Thamamongood, Martin Schwemmle, Katrin Pannhorst, Lisa Wendt, Thomas C. Mettenleiter, Barbara G. Klupp
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Viruses
Subjects:
herpesvirus
pseudorabies virus
PrV
gD<sup>–</sup>Pass
CRISPR/Cas9 gene editing
sphingomyelin synthase
Online Access:https://www.mdpi.com/1999-4915/13/8/1574

Internet

https://www.mdpi.com/1999-4915/13/8/1574

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