THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis.

THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis.

Apoptosis of cochlear hair cells is a key step towards age-related hearing loss. Although numerous genes have been implicated in the genetic causes of late-onset, progressive hearing loss, few show direct links to the proapoptotic process. By genome-wide linkage analysis and whole exome sequencing,...

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Bibliographic Details
Main Authors: Luping Zhang, Yu Gao, Ru Zhang, Feifei Sun, Cheng Cheng, Fuping Qian, Xuchu Duan, Guanyun Wei, Cheng Sun, Xiuhong Pang, Penghui Chen, Renjie Chai, Tao Yang, Hao Wu, Dong Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-08-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008953

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https://doi.org/10.1371/journal.pgen.1008953

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