The Role of PI3K in Met Driven Cancer: A Recap

The Receptor Tyrosine Kinase (RTK) Met, overexpressed or mutated in cancer, plays a major role in cancer progression and represents an attractive target for cancer therapy. However RTK inhibitors can lead to drug resistance, explaining the necessity to develop therapies that target downstream signal...

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Bibliographic Details
Main Authors: Alexia Hervieu, Stéphanie Kermorgant
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
Met
Akt
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2018.00086/full