TNF-α inhibitor therapy can improve the immune imbalance of CD4+ T cells and negative regulatory cells but not CD8+ T cells in ankylosing spondylitis

TNF-α inhibitor therapy can improve the immune imbalance of CD4+ T cells and negative regulatory cells but not CD8+ T cells in ankylosing spondylitis

Abstract Background Studies into ankylosing spondylitis (AS) and its relationship with immune imbalance are controversial, and the correlation between the efficacy of TNF-α inhibitor and changes in immune imbalance is unclear. Methods A total of 40 immune cells were tested with flow cytometry, and t...

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Bibliographic Details
Main Authors: Mingcan Yang, Qing Lv, Qiujing Wei, Yutong Jiang, Jun Qi, Min Xiao, Linkai Fang, Ya Xie, Shuangyan Cao, Zhiming Lin, Yanli Zhang, Liudan Tu, Minjing Zhao, Yunfeng Pan, Ou Jin, Jieruo Gu
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Arthritis Research & Therapy
Subjects:
Ankylosing spondylitis
CD4+ T cells
CD8+ T cells
Negative regulatory cells
TNF-α inhibitor
Online Access:http://link.springer.com/article/10.1186/s13075-020-02226-8

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http://link.springer.com/article/10.1186/s13075-020-02226-8

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