Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen

Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen

Neutrophils are essential for host defence and are recruited to sites of inflammation in response to tissue injury or infection. For inflammation to resolve, these cells must be cleared efficiently and in a controlled manner, either by apoptosis or reverse migration. If the inflammatory response is...

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Bibliographic Details
Main Authors: Anne L. Robertson, Nikolay V. Ogryzko, Katherine M. Henry, Catherine A. Loynes, Matthew J. Foulkes, Marco M. Meloni, Xingang Wang, Christopher Ford, Malcolm Jackson, Philip W. Ingham, Heather L. Wilson, Stuart N. Farrow, Roberto Solari, Roderick J. Flower, Simon Jones, Moira K. B. Whyte, Stephen A. Renshaw
Format: Article
Language:English
Published: The Company of Biologists 2016-06-01
Series:Disease Models & Mechanisms
Subjects:
Zebrafish
Inflammation
Neutrophil apoptosis
Chromone
Benzopyrone
Online Access:http://dmm.biologists.org/content/9/6/621

Internet

http://dmm.biologists.org/content/9/6/621

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